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The antibody against MFSD2A/NLS1 was raised in Rabbit using the recombinant protein of human MFSD2A/NLS1 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MFSD2A/NLS1 was raised in Rabbit using the recombinant protein of human MFSD2A/NLS1 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-15132A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MFSD2A/NLS1 |
| Target Synonyms | NLS1; MFSD2; MCPH15; SLC59A1; HsMFSD2A; NEDMISBA; MFSD2A/NLS1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293F, Mouse brain, Mouse heart(Negative control), Mouse spleen, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant protein of human MFSD2A/NLS1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NA29 |
Uniprot Id
Q8NA29
Target Species
Human
Target Name
MFSD2A
Target Full Name
Sodium-dependent lysophosphatidylcholine symporter 1
Target Function
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
Target Involvement
Microcephaly 15, primary, autosomal recessive (MCPH15)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Major facilitator superfamily
Target Tissue Specificity
In placenta, associated with trophoblast cells.
Target Synonyms
1700018O18Rik; FLJ14490; FLJ35904; Major facilitator superfamily domain containing 2; Major facilitator superfamily domain containing 2A; Major facilitator superfamily domain-containing protein 2A; MFS2A_HUMAN; MFSD2; MFSD2A; RGD1310174; RP23-121J14.3
Target Background
The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. The encoded protein is involved in the establishment of the blood-brain barrier and is required for brain growth and function. Defects in this gene are a cause of a progressive microcephaly syndrome.
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