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The antibody against MGLL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 11-313 of human MGLL (NP_009214.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MGLL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 11-313 of human MGLL (NP_009214.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-11088A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Mgll |
| Target Synonyms | MGL; HUK5; MAGL; HU-K5; MGLL | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Rat brain, Rat heart, A-549, HepG2, SH-SY5Y | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 11-313 of human MGLL (NP_009214.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q99685 | Immunogen Sequence |
Uniprot Id
Q99685
Target Species
Human
Target Name
MGLL
Target Full Name
Monoglyceride lipase
Target Function
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Target Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Target Protein Families
AB hydrolase superfamily, Monoacylglycerol lipase family
Target Tissue Specificity
Detected in adipose tissue, lung, liver, kidney, brain and heart.
Target Research Area
Cardiovascular
Target Synonyms
EC 3.1.1.23; HU K5 ; HU-K5; HUK5 ; Lysophospholipase homolog; Lysophospholipase like; Lysophospholipase-like; MAGL; MGL; MGLL; MGLL_HUMAN; Monoacylglycerol lipase; Monoglyceride lipase
Target Background
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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