Rabbit anti-Human MRPL2 Polyclonal Antibody

Uniprot Id

Q5T653

Target Species

Human

Target Name

MRPL2

Target Full Name

Large ribosomal subunit protein uL2m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL2 family

Target Synonyms

39S ribosomal protein L2; 39S ribosomal protein L2, mitochondrial precursor; CGI22; L2mt; mitochondrial; Mitochondrial ribosomal protein L2; MRP L14; MRP-L2; MRPL14; Mrpl2; RM02_HUMAN; RPML14

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms.