Rabbit anti-Human MRPS30 Polyclonal Antibody

Uniprot Id

Q9NP92

Target Species

Human

Target Name

MRPS30

Target Full Name

Large ribosomal subunit protein mL65

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL65 family

Target Tissue Specificity

Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.

Target Synonyms

28S ribosomal protein S30; 28S ribosomal protein S30; mitochondrial; Mitochondrial 28S ribosomal protein S30; mitochondrial; Mitochondrial ribosomal protein S30; MRP S30; MRP-S30; MRPS30; PAP; PDCD9; Programmed cell death 9; Programmed cell death protein 9; RT30_HUMAN; S30mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.