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Rabbit anti-Human MTMR8 Polyclonal Antibody

The antibody against MTMR8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-07049A

The antibody against MTMR8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

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Specifications


Cat.No ADA-07049A ClonalityPolyclonal
Host SpeciesRabbitTarget NameMTMR8
Target SynonymsMTMR8FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesHT-29, SKOV3, U-87MGApplicationELISA, WB, IHC-P

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2).Target SpeciesHuman
Immunogen SequenceHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQUniprot IDQ96EF0
Background Information
  • Uniprot Id

    Q96EF0

  • Target Species

    Human

  • Target Name

    MTMR8

  • Target Full Name

    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

  • Target Function

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. In complex with MTMR9, negatively regulates autophagy.

  • Target Subcellular Location

    Nucleus envelope.

  • Target Protein Families

    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily

  • Target Synonyms

    C8orf9; DKFZP434K171; FLJ20126; LIP STYX; MTMR8; MTMR8_HUMAN; MTMR9; Myotubularin related protein 8; Myotubularin related protein 9; Myotubularin-related protein 8

  • Target Background

    This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases.

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