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The antibody against MUT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 451-750 of human MUT (NP_000246.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against MUT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 451-750 of human MUT (NP_000246.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09778A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Mut |
| Target Synonyms | MCM; MUT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, 22Rv1, BT-474, LO2, Mouse liver, Mouse pancreas, Rat liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 451-750 of human MUT (NP_000246.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22033 | Immunogen Sequence |
Uniprot Id
P22033
Target Species
Human
Target Name
MMUT
Target Full Name
Methylmalonyl-CoA mutase, mitochondrial
Target Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
Target Involvement
Methylmalonic aciduria type mut (MMAM)
Target Subcellular Location
Mitochondrion matrix. Mitochondrion. Cytoplasm.
Target Protein Families
Methylmalonyl-CoA mutase family
Target Research Area
Signal Transduction
Target Synonyms
MCM; Methylmalonyl CoA isomerase ; Methylmalonyl CoA mutase mitochondrial; Methylmalonyl Coenzyme A mutase; Methylmalonyl-CoA isomerase; Methylmalonyl-CoA mutase; mitochondrial; Mut; MUTA_HUMAN
Target Background
This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
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