Rabbit anti-Human NAA10 Polyclonal Antibody

Uniprot Id

P41227

Target Species

Human

Target Name

NAA10

Target Full Name

N-alpha-acetyltransferase 10

Target Function

Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis.

Target Involvement

N-terminal acetyltransferase deficiency (NATD); Microphthalmia, syndromic, 1 (MCOPS1)

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Acetyltransferase family, ARD1 subfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Alpha N acetyltransferase 1A; ARD1; ARD1 homolog N acetyltransferase (S. cerevisiae); ARD1 homolog A N acetyltransferase (S. cerevisiae); ARD1 homolog A N acetyltransferase; ARD1A; DXS707; MGC71248; N acetyltransferase ARD1, human homolog of; N alpha acetyltransferase 10 NatA catalytic subunit; N terminal acetyltransferase complex ARD1 subunit homolog A; N(alpha) acetyltransferase 10 NatA catalytic subunit; N-alpha-acetyltransferase 10; N-terminal acetyltransferase complex ARD1 subunit homolog A; Naa10; NAA10_HUMAN; NatA catalytic subunit; TE2

Target Background

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants.