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The antibody against NEK9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 730-979 of human NEK9 (NP_149107.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NEK9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 730-979 of human NEK9 (NP_149107.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-07108A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NEK9 |
| Target Synonyms | NC; APUG; NERCC; LCCS10; NERCC1; NEK9 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, HepG2, Raji, Rat lung, Rat spleen, Rat thymus | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 730-979 of human NEK9 (NP_149107.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TD19 | Immunogen Sequence |
Uniprot Id
Q8TD19
Target Species
Human
Target Name
NEK9
Target Full Name
Serine/threonine-protein kinase Nek9
Target Function
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
Target Involvement
Lethal congenital contracture syndrome 10 (LCCS10); Nevus comedonicus (NC); Arthrogryposis, Perthes disease, and upward gaze palsy (APUG)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Target Tissue Specificity
Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
Target Synonyms
KIAA1995; APUG; DKFZp434D0935; LCCS10; MGC138306; MGC16714; NC; NEK 9; Nek8; nek9; NEK9_HUMAN; Nercc 1 kinase; NERCC; NERCC1; Nercc1 kinase; Never in mitosis A related kinase 9; Never in mitosis A-related kinase 9; NIMA (never in mitosis gene a) related kinase 9; NIMA related kinase 8; NIMA related kinase 9; NIMA related kinase Nek8 ; NimA related protein kinase 9; NIMA-related kinase 8; NimA-related protein kinase 9; Serine/threonine protein kinase Nek9 ; Serine/threonine-protein kinase Nek9
Target Background
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression.
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