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The antibody against NOP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 355-590 of human NOP2 (NP_001245237.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NOP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 355-590 of human NOP2 (NP_001245237.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07243A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOP2 |
| Target Synonyms | NOL1; p120; NSUN1; NOP120; NOP2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Jurkat, Mouse liver, Mouse placenta, Mouse thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 355-590 of human NOP2 (NP_001245237.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P46087 | Immunogen Sequence |
Uniprot Id
P46087
Target Species
Human
Target Name
NOP2
Target Full Name
28S rRNA (cytosine(4447)-C(5))-methyltransferase
Target Function
Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
Target Synonyms
NOP2; NOL1; NSUN1Probable 28S rRNA; cytosine(4447)-C(5))-methyltransferase; EC 2.1.1.-; Nucleolar protein 1; Nucleolar protein 2 homolog; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar protein p120
Target Background
Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus.
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