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The antibody against NPR3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human NPR3 (NP_001191304.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against NPR3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human NPR3 (NP_001191304.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02010A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NPR3 |
| Target Synonyms | NPRC; ANP-C; ANPRC; BOMOS; NPR-C; ANPR-C; GUCY2B; C5orf23; NPR3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, Rat heart, Mouse lung, NCI-H460 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human NPR3 (NP_001191304.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P17342 | Immunogen Sequence |
Uniprot Id
P17342
Target Species
Human
Target Name
NPR3
Target Full Name
Atrial natriuretic peptide receptor 3
Target Function
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
ANF receptor family
Target Research Area
Signal Transduction
Target Synonyms
NPR3; ANPRC; C5orf23; NPRC; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
Target Background
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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