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The antibody against NQO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-231 of human NQO2 (NP_000895.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NQO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-231 of human NQO2 (NP_000895.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02053A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NQO2 |
| Target Synonyms | QR2; DHQV; DIA6; NMOR2; NQO2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, LO2, Mouse liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-231 of human NQO2 (NP_000895.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P16083 | Immunogen Sequence |
Uniprot Id
P16083
Target Species
Human
Target Name
NQO2
Target Full Name
Ribosyldihydronicotinamide dehydrogenase [quinone]
Target Function
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Target Subcellular Location
Cytoplasm.
Target Protein Families
NAD(P)H dehydrogenase (quinone) family
Target Synonyms
DHQV; DIA6; EC 1.10.99.2; MGC94180; NAD(P)H dehydrogenase quinone 2; NAD(P)H menadione oxidoreductase 1 dioxin inducible 2; NAD(P)H menadione oxidoreductase 2 dioxin inducible ; NMOR2; NQO 2; NQO2; NQO2_HUMAN; NRH dehydrogenase [quinone] 2; NRH dehydrogenase; NRH:quinone oxidoreductase 2; OTTHUMP00000015948; OTTHUMP00000015949; OTTHUMP00000015953; Ox 2; Ox2; QR2; Quinone; Quinone reductase 2; Ribosyldihydronicotinamide dehydrogenase [quinone]; Ribosyldihydronicotinamide dehydrogenase
Target Background
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants.
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