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The antibody against NSL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human NSL1 (NP_056286.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against NSL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human NSL1 (NP_056286.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Immunofluorescence analysis of A549 cells using NSL1 antibody.
| Cat.No | ADA-02693A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NSL1 |
| Target Synonyms | DC8; MIS14; C1orf48; NSL1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human NSL1 (NP_056286.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96IY1 | Immunogen Sequence |
Uniprot Id
Q96IY1
Target Species
Human
Target Name
NSL1
Target Full Name
Kinetochore-associated protein NSL1 homolog
Target Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore (PubMed:15502821, PubMed:16585270).
Target Synonyms
4833432M17Rik; AI451597; C1orf48; DC31; DC8; DKFZp566O1646; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; Kinetochore-associated protein NSL1 homolog; MIS14; NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); NSL1_HUMAN
Target Background
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X.
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