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The antibody against NSMAF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NSMAF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04869A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NSMAF |
| Target Synonyms | FAN; GRAMD5; NSMAF | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q92636 | Immunogen Sequence |
Uniprot Id
Q92636
Target Species
Human
Target Name
NSMAF
Target Full Name
Protein FAN
Target Function
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
NSMAF; FANProtein FAN; Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation
Target Background
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
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