Rabbit anti-Human P2RY12 Polyclonal Antibody

The antibody against P2RY12 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 243-342 of human P2RY12 (NP_795345.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-04534A

Number

Cat.No	ADA-04534A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	P2RY12
Target Synonyms	HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc); P2RY12	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse brain	Application	ELISA, WB, IF/ICC

Cat.No

ADA-04534A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

P2RY12

Target Synonyms

HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc); P2RY12

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse brain

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 243-342 of human P2RY12 (NP_795345.1).	Target Species	Human
Immunogen Sequence	AVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM	Uniprot ID	Q9H244

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 243-342 of human P2RY12 (NP_795345.1).

Target Species

Human

Immunogen Sequence

AVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM

Uniprot ID

Q9H244

Background Information

Uniprot Id

Q9H244
Target Species

Human
Target Name

P2RY12
Target Full Name

P2Y purinoceptor 12
Target Function

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Target Involvement

Bleeding disorder, platelet-type 8 (BDPLT8)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

G-protein coupled receptor 1 family
Target Tissue Specificity

Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Target Synonyms

P2RY12; HORK3; P2Y purinoceptor 12; P2Y12; ADP-glucose receptor; ADPG-R; P2T(AC; P2Y(AC; P2Y(cyc; P2Y12 platelet ADP receptor; P2Y(ADP; SP1999
Target Background

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.

Rabbit anti-Human P2RY12 Polyclonal Antibody

Specifications

Immunogen Information

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