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The antibody against P4HA1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 235-534 of human P4HA1 (NP_001017962.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against P4HA1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 235-534 of human P4HA1 (NP_001017962.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-10930A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | P4HA1 |
| Target Synonyms | P4HA; P4HA1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, NCI-H460, Rat skeletal muscle, U-251MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 235-534 of human P4HA1 (NP_001017962.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P13674 | Immunogen Sequence |
Uniprot Id
P13674
Target Species
Human
Target Name
P4HA1
Target Full Name
Prolyl 4-hydroxylase subunit alpha-1
Target Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
P4HA family
Target Research Area
Signal Transduction
Target Synonyms
2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; Prolyl 4-hydroxylase subunit alpha-1
Target Background
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
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