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The antibody against PAICS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_001072992.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PAICS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_001072992.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09482A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAICS |
| Target Synonyms | ADE2; AIRC; PAIS; ADE2H1; PAICSD; PAICS | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, Jurkat, Raji, SW620 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_001072992.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22234 | Immunogen Sequence |
Uniprot Id
P22234
Target Species
Human
Target Name
PAICS
Target Full Name
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Target Synonyms
ADE2; ADE2H1; AIR carboxylase; AIRC; DKFZp781N1372; MGC1343; MGC5024; Multifunctional protein ADE2; Multifunctional protein ADE2H1; Paics; PAIS; Phosphoribosylaminoimidazole carboxylase; Phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole succinocarboxamide synthetase; PUR6_HUMAN; SAICAR synthetase
Target Background
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
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