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The antibody against PDE4C was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against PDE4C was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of PC-12 cells using PDE4C Rabbit pAb at dilution of 1:400 (40x lens).Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
| Cat.No | ADA-03386A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE4C |
| Target Synonyms | DPDE1; PDE21; PDE4C | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | IPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT | Uniprot ID | Q08493 |
Uniprot Id
Q08493
Target Species
Human
Target Name
PDE4C
Target Full Name
3',5'-cyclic-AMP phosphodiesterase 4C
Target Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Target Subcellular Location
Cell projection, cilium.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Target Tissue Specificity
Expressed in various tissues but not in cells of the immune system.
Target Synonyms
DPDE1; PDE21; PDE4C
Target Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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