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The antibody against PGC was raised in mouse using the Recombinant Human PGC as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G purifed . This antibody has been validated on ELISA, IHC.
The antibody against PGC was raised in mouse using the Recombinant Human PGC as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G purifed . This antibody has been validated on ELISA, IHC.
$350.00
Immunohistochemical of paraffin-embedded human gastric cancer tissue using PGC Monoclonal Antibody at dilution of 1:200
| Cat.No | ADC-55477A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | PGC |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG1 | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human PGC | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P20142 |
Uniprot Id
P20142
Target Species
Human
Target Name
PGC
Target Full Name
Gastricsin
Target Function
Hydrolyzes a variety of proteins.
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase A1 family
Target Synonyms
PEPC; PGII; Pepsinogen II (PG II)
Target Background
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
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