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The antibody against Phospho-GAB1-Y659 was raised in Rabbit using a synthetic phosphorylated peptide around Y659 of human GAB1 (NP_002030.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Phospho-GAB1-Y659 was raised in Rabbit using a synthetic phosphorylated peptide around Y659 of human GAB1 (NP_002030.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06612A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Phospho-GAB1-Y659 |
| Target Synonyms | DFNB26; Phospho-GAB1-Y659 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | NIH/3T3 | Application | ELISA, WB |
| Immunogen Description | A synthetic phosphorylated peptide around Y659 of human GAB1 (NP_002030.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | VDYVV | Uniprot ID | Q13480 |
Uniprot Id
Q13480
Target Species
Human
Target Name
GAB1
Target Full Name
GRB2-associated-binding protein 1
Target Function
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
Target Protein Families
GAB family
Target Synonyms
Gab 1; GAB1; GAB1_HUMAN; GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform b; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1
Target Background
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
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