Rabbit anti-Human Phospho-PFKFB2-S483 Polyclonal Antibody

Uniprot Id

O60825

Target Species

Human

Target Name

PFKFB2

Target Full Name

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

Target Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Target Protein Families

Phosphoglycerate mutase family

Target Tissue Specificity

Heart.

Target Synonyms

6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 ; 6-bisphosphatase; 6-P2ase 2; 6-P2ASE heart-type isozyme; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme; 6PF-2-K/Fru-2; 6PF-2-K/Fru-26-P2ase 2; 6PF-2-K/Fru-26-P2ase heart-type isozyme; F262_HUMAN; Fructose 2 6 bisphosphatase cardiac isozyme; Fructose-2; PFK 2/FBPase 2; PFK/FBPase 2; PFKFB cardiac ; PFKFB2

Target Background

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate, and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. This protein regulates fructose-2, 6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2, 6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.