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The antibody against PLCH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human PLCH1 (NP_055811.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PLCH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human PLCH1 (NP_055811.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03324A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLCH1 |
| Target Synonyms | HPE14; PLCL3; PLC-L3; PLC eta 1; PLCH1 | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human PLCH1 (NP_055811.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q4KWH8 | Immunogen Sequence |
Uniprot Id
Q4KWH8
Target Species
Human
Target Name
PLCH1
Target Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Target Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Target Subcellular Location
Cytoplasm. Membrane.
Target Tissue Specificity
Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.
Target Synonyms
1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1; 5-bisphosphate phosphodiesterase eta-1; DKFZp434C1372; KIAA1069; MGC117152; Phosphoinositide phospholipase C-eta-1; Phospholipase C-eta-1; Phospholipase C-like protein 3; PLC-eta-1; PLC-L3; PLCeta1; Plch1; PLCH1_HUMAN; PLCL3
Target Background
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) to generate second messengers inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).
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