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The antibody against PPAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PPAN (NP_064615.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against PPAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PPAN (NP_064615.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-02542A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPAN |
| Target Synonyms | SSF; SSF1; SSF2; BXDC3; SSF-1; PPAN | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, U-87MG | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PPAN (NP_064615.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NQ55 | Immunogen Sequence |
Uniprot Id
Q9NQ55
Target Species
Human
Target Name
PPAN
Target Full Name
Suppressor of SWI4 1 homolog
Target Function
May have a role in cell growth.
Target Subcellular Location
Nucleus, nucleolus.
Target Tissue Specificity
Widely expressed.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Brix domain containing protein 3; Brix domain-containing protein 3; BXDC3; Homolog of S. cerevisiae SSF1; Peter pan homolog (Drosophila); Peter Pan homolog; PPAN; Second step splicing factor 1; SSF 1; SSF; Ssf-1; SSF1; SSF1_HUMAN; SSF2; Suppressor of sterile four 1; Suppressor of SWI4 1 homolog
Target Background
The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation.
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