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The antibody against PVRIG was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 193-326 of human PVRIG (NP_076975.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PVRIG was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 193-326 of human PVRIG (NP_076975.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07671A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PVRIG |
| Target Synonyms | CD112R; C7orf15; PVRIG | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Daudi, HeLa(negative) | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 193-326 of human PVRIG (NP_076975.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | LRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR | Uniprot ID | Q6DKI7 |
Uniprot Id
Q6DKI7
Target Species
Human
Target Name
PVRIG
Target Full Name
Transmembrane protein PVRIG
Target Function
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Tissue Specificity
Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
Target Synonyms
PVRIG; C7orf15; Transmembrane protein PVRIG; CD112 receptor; CD112R; Poliovirus receptor-related immunoglobulin domain-containing protein
Target Background
Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane.
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