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The antibody against PYGB was raised in rabbit using the Recombinant Human Glycogen phosphorylase, brain form protein (6-843AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against PYGB was raised in rabbit using the Recombinant Human Glycogen phosphorylase, brain form protein (6-843AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using PYGB Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using PYGB Antibody at dilution of 1:1002
| Cat.No | ADC-54251A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PYGB |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Glycogen phosphorylase, brain form protein (6-843AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P11216 |
Uniprot Id
P11216
Target Species
Human
Target Name
PYGB
Target Full Name
Glycogen phosphorylase, brain form
Target Function
Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Target Protein Families
Glycogen phosphorylase family
Target Research Area
Metabolism
Target Synonyms
Brain glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; Glycogen Phosphorylase Isoenzyme BB; Glycogen phosphorylase; brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN
Target Background
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
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