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The antibody against QDPR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human QDPR (NP_000311.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against QDPR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human QDPR (NP_000311.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10796A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | QDPR |
| Target Synonyms | DHPR; PKU2; HDHPR; SDR33C1; QDPR | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, BT-474, HL-60, Mouse brain, Mouse liver, Rat liver, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human QDPR (NP_000311.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P09417 | Immunogen Sequence |
Uniprot Id
P09417
Target Species
Human
Target Name
QDPR
Target Full Name
Dihydropteridine reductase
Target Function
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Target Involvement
Hyperphenylalaninemia, BH4-deficient, C (HPABH4C)
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Synonyms
6,7 dihydropteridine reductase; DHPR; DHPR_HUMAN; Dihydropteridine reductase; HDHPR; HPR; PKU2; Qdpr; Quinoid dihydropteridine reductase; SDR33C1; Short chain dehydrogenase/reductase family 33C, member 1
Target Background
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.
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