Rabbit anti-Human RIMS2 Polyclonal Antibody

Uniprot Id

Q9UQ26

Target Species

Human

Target Name

RIMS2

Target Full Name

Regulating synaptic membrane exocytosis protein 2

Target Function

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.

Target Subcellular Location

Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.

Target Tissue Specificity

Widely expressed. Expressed in melanocytes. In fetal tissues, predominantly expressed in the brain. In the retina, expressed in the outer plexiform layer (at protein level). In the cerebellum, expressed in Purkinje cells (at protein level). In the pancrea

Target Synonyms

KIAA0751; Non small cell lung cancer RimL3a protein; Non small cell lung cancer RimL3c protein; OBOE; Protein regulating synaptic membrane exocytosis 2; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; Rab3 interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rims2 (gene name); Rims2; RIMS2_HUMAN

Target Background

The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis.