Rabbit anti-Human RMI2 Polyclonal Antibody

The antibody against RMI2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01213A

Number

Cat.No	ADA-01213A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	RMI2
Target Synonyms	BLAP18; C16orf75; RMI2	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, MCF7	Application	ELISA, WB

Cat.No

ADA-01213A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

RMI2

Target Synonyms

BLAP18; C16orf75; RMI2

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, MCF7

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1).	Target Species	Human
Immunogen Sequence	MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYVMVMGVVQACSPEPCLQAVKMTDLSDNPIHESMWELEVEDLHRNIP	Uniprot ID	Q96E14

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1).

Target Species

Human

Immunogen Sequence

MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYVMVMGVVQACSPEPCLQAVKMTDLSDNPIHESMWELEVEDLHRNIP

Uniprot ID

Q96E14

Background Information

Uniprot Id

Q96E14
Target Species

Human
Target Name

RMI2
Target Full Name

RecQ-mediated genome instability protein 2
Target Function

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
Target Involvement

A homozygous deletion of RMI2 has been found in a family with a Bloom-like syndrome and is probable responsible for the phenotype. Patients manifest depigmented skin lesions, multiple cafe-au-lait macules, and growth deficiency. Cells from affected individuals show a high rate of sister chromatid exchange and increased chromosomal breaks.
Target Subcellular Location

Nucleus. Note=Colocalizes with BLM at nuclear DNA repair foci.
Target Protein Families

RMI2 family
Target Synonyms

BLAP18; BLM-associated protein of 18 kDa; C16orf75; hRMI2; MGC24665; RecQ-mediated genome instability protein 2; RMI2; RMI2_HUMAN
Target Background

RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).

Rabbit anti-Human RMI2 Polyclonal Antibody

Specifications

Immunogen Information

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