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The antibody against RNF220 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 267-566 of human RNF220 (NP_060620.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RNF220 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 267-566 of human RNF220 (NP_060620.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10045A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF220 |
| Target Synonyms | HLD23; C1orf164; RNF220 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, U-937 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 267-566 of human RNF220 (NP_060620.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5VTB9 | Immunogen Sequence |
Uniprot Id
Q5VTB9
Target Species
Human
Target Name
RNF220
Target Full Name
E3 ubiquitin-protein ligase RNF220
Target Function
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling.
Target Subcellular Location
Cytoplasm.
Target Synonyms
RNF220; C1orf164; E3 ubiquitin-protein ligase RNF220; EC 2.3.2.27; RING finger protein 220; RING-type E3 ubiquitin transferase RNF220
Target Background
Predicted to enable ubiquitin protein ligase activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of protein-containing complex.
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