Rabbit anti-Human RPL13 Polyclonal Antibody

Uniprot Id

P26373

Target Species

Human

Target Name

RPL13

Target Full Name

Large ribosomal subunit protein eL13

Target Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Eukaryotic ribosomal protein eL13 family

Target Tissue Specificity

Higher levels of expression in benign breast lesions than in carcinomas.

Target Synonyms

60S ribosomal protein L13; BBC1; Breast basic conserved gene 1; Breast basic conserved protein 1; D16S444E ; D16S44E; FLJ27453 ; FLJ27454 ; L13; MGC117342 ; MGC71373 ; OK/SW cl.46; OK/SWcl.46; Ribosomal protein L13; RL13_HUMAN; rpl13

Target Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.