Rabbit anti-Human SARS Polyclonal Antibody

The antibody against SARS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SARS (NP_006504.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09612A

Number

Cat.No	ADA-09612A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SARS
Target Synonyms	SARS; SERS; SERRS; NEDMAS	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse kidney, 293T, HepG2, MCF7, Mouse brain, U-251MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-09612A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SARS

Target Synonyms

SARS; SERS; SERRS; NEDMAS

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse kidney, 293T, HepG2, MCF7, Mouse brain, U-251MG

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SARS (NP_006504.2).	Target Species	Human
Uniprot ID	P49591	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SARS (NP_006504.2).

Target Species

Human

Uniprot ID

P49591

Immunogen Sequence

Background Information

Uniprot Id

P49591
Target Species

Human
Target Name

SARS
Target Full Name

Serine--tRNA ligase, cytoplasmic
Target Function

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
Target Tissue Specificity

Brain.
Target Research Area

Metabolism
Target Synonyms

C78314; cytoplasmic; EC 6.1.1.11; FLJ36399; sarS; Sars1; Serine tRNA ligase 1, cytoplasmic; Serine tRNA ligase; Serine--tRNA ligase; serine--tRNA ligase, cytoplasmic; SerRS; SERS; Seryl tRNA Ser/Sec synthetase; Seryl tRNA synthetase; Seryl tRNA synthetase cytoplasmic; Seryl-tRNA Ser/Sec synthetase; Seryl-tRNA synthetase; seryl-tRNA synthetase, cytoplasmic; Seryl-tRNA(Ser/Sec) synthetase; Strs; SYSC_HUMAN
Target Background

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown.

Rabbit anti-Human SARS Polyclonal Antibody

Specifications

Immunogen Information

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