Rabbit anti-Human SOX18 Polyclonal Antibody

The antibody against SOX18 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX18 (NP_060889.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00224A

Number

Cat.No	ADA-00224A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SOX18
Target Synonyms	HLTS; HLTRS; SOX18	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung, Rat kidney	Application	ELISA, WB

Cat.No

ADA-00224A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SOX18

Target Synonyms

HLTS; HLTRS; SOX18

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung, Rat kidney

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX18 (NP_060889.1).	Target Species	Human
Immunogen Sequence	MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDER	Uniprot ID	P35713

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX18 (NP_060889.1).

Target Species

Human

Immunogen Sequence

MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDER

Uniprot ID

P35713

Background Information

Uniprot Id

P35713
Target Species

Human
Target Name

SOX18
Target Full Name

Transcription factor SOX-18
Target Function

Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.
Target Involvement

Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS); Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (HLTRS)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon.
Target Synonyms

HLTS; SOX 18; Sox18; SOX18_HUMAN; SRY (sex determining region Y) box 18; SRY box 18; Transcription factor SOX 18; Transcription factor SOX-18
Target Background

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.

Rabbit anti-Human SOX18 Polyclonal Antibody

Specifications

Immunogen Information

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