Rabbit anti-Human SUPT5H/SPT5 Polyclonal Antibody

Uniprot Id

O00267

Target Species

Human

Target Name

SUPT5H

Target Full Name

Transcription elongation factor SPT5

Target Function

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences

Target Subcellular Location

Nucleus.

Target Protein Families

SPT5 family

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

DRB sensitivity inducing factor large subunit; DRB sensitivity-inducing factor 160 kDa subunit; DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; FLJ34157; hSPT 5; hSPT5; SPT 5; SPT 5H; SPT5; SPT5H; SPT5H_HUMAN; Suppressor of Ty 5 homolog; Suppressor of Ty 5 homolog (S. cerevisiae); SUPT 5H; supt5h; Tat cotransactivator 1 protein; Tat CT1; Tat CT1 protein; Tat-cotransactivator 1 protein; Tat-CT1 protein; Transcription elongation factor SPT 5; Transcription elongation factor spt5; Transcription factor Tat CT1