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The antibody against TDRKH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 36-355 of human TDRKH (NP_001077432.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TDRKH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 36-355 of human TDRKH (NP_001077432.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02852A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TDRKH |
| Target Synonyms | TDRD2; TDRKH | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HepG2, MCF7, Mouse testis, Rat testis, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 36-355 of human TDRKH (NP_001077432.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2W6 | Immunogen Sequence |
Uniprot Id
Q9Y2W6
Target Species
Human
Target Name
TDRKH
Target Full Name
Tudor and KH domain-containing protein
Target Function
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Target Subcellular Location
Cytoplasm. Mitochondrion.
Target Protein Families
Tdrkh family
Target Synonyms
2700091C21Rik; Putative RNA binding protein; RGD1311196; RP11-98D18.8; TDRD2; TDRD7; Tdrkh; TDRKH_HUMAN; Tudor and KH domain containing; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2
Target Background
Predicted to enable RNA binding activity. Predicted to be involved in fertilization; gamete generation; and piRNA metabolic process. Predicted to be located in mitochondrion; pi-body; and piP-body.
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