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The antibody against THSD7A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 48-350 of human THSD7A (NP_056019.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against THSD7A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 48-350 of human THSD7A (NP_056019.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00175A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THSD7A |
| Target Synonyms | THSD7A | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 48-350 of human THSD7A (NP_056019.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UPZ6 | Immunogen Sequence |
Uniprot Id
Q9UPZ6
Target Species
Human
Target Name
THSD7A
Target Full Name
Thrombospondin type-1 domain-containing protein 7A
Target Function
Plays a role in actin cytoskeleton rearrangement.; The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
Target Subcellular Location
[Thrombospondin type-1 domain-containing protein 7A]: Cell membrane; Single-pass type I membrane protein. Cell projection.; [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted.
Target Tissue Specificity
Detected on kidney podocytes along the glomerular capillary wall (at protein level).
Target Synonyms
Thrombospondin type-1 domain-containing protein 7A; THS7A_HUMAN; Thsd7a
Target Background
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis.
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