Rabbit anti-Human TIMM50 Polyclonal Antibody

Uniprot Id

Q3ZCQ8

Target Species

Human

Target Name

TIMM50

Target Full Name

Mitochondrial import inner membrane translocase subunit TIM50

Target Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.; May participate in the release of snRNPs and SMN from the Cajal body.

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.; [Isoform 2]: Nucleus speckle.

Target Protein Families

TIM50 family

Target Tissue Specificity

Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).

Target Synonyms

TIMM50; TIM50; PRO1512; Mitochondrial import inner membrane translocase subunit TIM50

Target Background

This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis.