Rabbit anti-Human TLE4 Polyclonal Antibody

The antibody against TLE4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 173-243 of human TLE4 (NP_001269677) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00473A

Number

Cat.No	ADA-00473A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TLE4
Target Synonyms	ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl); TLE4	Form	Liquid
Species Reactivity	Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat lung	Application	ELISA, WB

Cat.No

ADA-00473A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TLE4

Target Synonyms

ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl); TLE4

Form

Liquid

Species Reactivity

Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 173-243 of human TLE4 (NP_001269677).	Target Species	Human
Immunogen Sequence	SSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARY	Uniprot ID	Q04727

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 173-243 of human TLE4 (NP_001269677).

Target Species

Human

Immunogen Sequence

SSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARY

Uniprot ID

Q04727

Background Information

Uniprot Id

Q04727
Target Species

Human
Target Name

TLE4
Target Full Name

Transducin-like enhancer protein 4
Target Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
Target Subcellular Location

Nucleus.
Target Protein Families

WD repeat Groucho/TLE family
Target Tissue Specificity

In all tissues examined, mostly in brain, and muscle.
Target Synonyms

ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl); TLE4
Target Background

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex.

Rabbit anti-Human TLE4 Polyclonal Antibody

Specifications

Immunogen Information

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