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The antibody against TNFRSF17 was raised in mouse using the Recombinant Human TNFRSF17 protein (1-54AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2b, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against TNFRSF17 was raised in mouse using the Recombinant Human TNFRSF17 protein (1-54AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2b, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Western Blot Positive WB detected in: 1-2 lanes: 293F whole cell lysate transfected with BCMA; 3-4 lane: Recombinant proteins with BCMA All lanes: TNFRSF17 antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size: 40, 15 KDa Observed band size: 40, 15 KDa Exposure time:10min
| Cat.No | ADC-56081A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | TNFRSF17 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG2b | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human TNFRSF17 protein (1-54AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q02223 |
Uniprot Id
Q02223
Target Species
Human
Target Name
TNFRSF17
Target Full Name
Tumor necrosis factor receptor superfamily member 17
Target Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Target Involvement
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Target Tissue Specificity
Expressed in mature B-cells, but not in T-cells or monocytes.
Target Research Area
Cancer
Target Synonyms
BCM; BCMA; CD269; TNFRSF13A; TNFRSF17
Target Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
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