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The antibody against TRNT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 135-434 of human TRNT1 (NP_886552.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TRNT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 135-434 of human TRNT1 (NP_886552.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10520A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRNT1 |
| Target Synonyms | CCA1; RPEM; SIFD; MtCCA; CGI-47; TRNT1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, A-549, Rat lung, Rat spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 135-434 of human TRNT1 (NP_886552.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96Q11 | Immunogen Sequence |
Uniprot Id
Q96Q11
Target Species
Human
Target Name
TRNT1
Target Full Name
CCA tRNA nucleotidyltransferase 1, mitochondrial
Target Function
Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.; Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).
Target Involvement
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD); Retinitis pigmentosa and erythrocytic microcytosis (RPEM)
Target Subcellular Location
Mitochondrion.
Target Protein Families
TRNA nucleotidyltransferase/poly(A) polymerase family
Target Synonyms
TRNT1; CGI-47; CCA tRNA nucleotidyltransferase 1; mitochondrial; EC 2.7.7.72; Mitochondrial tRNA nucleotidyl transferase; CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase
Target Background
The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants.
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