Rabbit anti-Human TUB Polyclonal Antibody

The antibody against TUB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 130-230 of human TUB (NP_003311.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-06931A

Number

Cat.No	ADA-06931A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TUB
Target Synonyms	rd5; RDOB; TUB	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	PC-3, U-251MG, U-87MG	Application	ELISA, WB

Cat.No

ADA-06931A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TUB

Target Synonyms

rd5; RDOB; TUB

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

PC-3, U-251MG, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 130-230 of human TUB (NP_003311.2).	Target Species	Human
Immunogen Sequence	LSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGER	Uniprot ID	P50607

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 130-230 of human TUB (NP_003311.2).

Target Species

Human

Immunogen Sequence

LSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGER

Uniprot ID

P50607

Background Information

Uniprot Id

P50607
Target Species

Human
Target Name

TUB
Target Full Name

Tubby protein homolog
Target Function

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
Target Involvement

Retinal dystrophy and obesity (RDOB)
Target Subcellular Location

Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

TUB family
Target Synonyms

F10B5.4; rd5; TUB 1; TUB; TUB_HUMAN; Tubby homologue; Tubby protein homolog 1; Tubby protein homolog
Target Background

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.

Rabbit anti-Human TUB Polyclonal Antibody

Specifications

Immunogen Information

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