Rabbit anti-Human UNG Polyclonal Antibody

The antibody against UNG was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-06306A

Number

Cat.No	ADA-06306A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	UNG
Target Synonyms	DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; UNG	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Jurkat, MCF7	Application	ELISA, WB, IHC-P

Cat.No

ADA-06306A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

UNG

Target Synonyms

DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; UNG

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Jurkat, MCF7

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1).	Target Species	Human
Uniprot ID	P13051	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1).

Target Species

Human

Uniprot ID

P13051

Immunogen Sequence

Background Information

Uniprot Id

P13051
Target Species

Human
Target Name

UNG
Target Full Name

Uracil-DNA glycosylase
Target Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Target Involvement

Immunodeficiency with hyper-IgM 5 (HIGM5)
Target Subcellular Location

[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
Target Protein Families

Uracil-DNA glycosylase (UDG) superfamily, UNG family
Target Tissue Specificity

Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
Target Synonyms

DGU; DKFZp781L1143; HIGM 4; HIGM4; OTTHUMP00000240527; OTTHUMP00000240528; OTTHUMP00000240529; UDG; UNG 1; UNG 15; ung; UNG_HUMAN; UNG1; UNG15; UNG2; Uracil DNA glycosylase 1; Uracil DNA glycosylase 2; Uracil DNA glycosylase; Uracil-DNA glycosylase
Target Background

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.

Rabbit anti-Human UNG Polyclonal Antibody

Specifications

Immunogen Information

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