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The antibody against VISTA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 33-194 of human VISTA (NP_071436.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against VISTA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 33-194 of human VISTA (NP_071436.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06441A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VISTA |
| Target Synonyms | B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549, LO2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 33-194 of human VISTA (NP_071436.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | FKVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVVYPSSSQDSENITAA | Uniprot ID | Q9H7M9 |
Uniprot Id
Q9H7M9
Target Species
Human
Target Name
VSIR
Target Full Name
V-type immunoglobulin domain-containing suppressor of T-cell activation
Target Function
Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
Target Research Area
Cardiovascular
Target Synonyms
B7 H5; B7H5; C10orf54; chromosome 10 open reading frame 54; DD1alpha; GI24; GI24_HUMAN; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; sisp 1; SISP1; stress induced secreted protein 1; UNQ730/PRO1412; V domain Ig suppressor of T cell activation; V set domain containing immunoregulatory receptor; V set immunoregulatory receptor; V type immunoglobulin domain containing suppressor of T cell activation; VISTA
Target Background
Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.
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