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The antibody against VPS13A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human VPS13A (NP_150648.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against VPS13A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human VPS13A (NP_150648.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06732A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VPS13A |
| Target Synonyms | CHAC; BLTP5A; CHOREIN; VPS13A | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human VPS13A (NP_150648.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96RL7 | Immunogen Sequence |
Uniprot Id
Q96RL7
Target Species
Human
Target Name
VPS13A
Target Full Name
Intermembrane lipid transfer protein VPS13A
Target Function
Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation.
Target Involvement
Choreoacanthocytosis (CHAC)
Target Subcellular Location
Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Lipid droplet. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Target Protein Families
VPS13 family
Target Tissue Specificity
Widely expressed. Higher expression is found in brain, heart, skeletal muscle and kidney.
Target Research Area
Neuroscience
Target Synonyms
VPS13A; CHAC; KIAA0986; Vacuolar protein sorting-associated protein 13A; Chorea-acanthocytosis protein; Chorein
Target Background
The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants.
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