Rabbit anti-Human WDR36 Polyclonal Antibody

Uniprot Id

Q8NI36

Target Species

Human

Target Name

WDR36

Target Full Name

WD repeat-containing protein 36

Target Function

Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.

Target Involvement

Glaucoma 1, open angle, G (GLC1G)

Target Subcellular Location

Nucleus, nucleolus.

Target Tissue Specificity

Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.

Target Synonyms

WDR36; WD repeat-containing protein 36; T-cell activation WD repeat-containing protein; TA-WDRP

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).