Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), Truncated

Uniprot Id

Q9NUQ2

Target Species

Human

Target Name

AGPAT5

Target Full Name

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Target Function

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion.

Target Protein Families

1-acyl-sn-glycerol-3-phosphate acyltransferase family

Target Tissue Specificity

Widely expressed.

Target Synonyms

AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5; 1-AGP acyltransferase 5; 1-AGPAT 5; Lysophosphatidic acid acyltransferase epsilon; LPAAT-epsilon

Target Background

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome.