Recombinant Human 14-3-3 protein sigma (SFN)

Uniprot Id

P31947

Target Species

Human

Target Name

SFN

Target Full Name

14-3-3 protein sigma

Target Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.; p53-regulated inhibitor of G2/M progression.

Target Subcellular Location

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Target Protein Families

14-3-3 family

Target Tissue Specificity

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Target Research Area

Neuroscience

Target Synonyms

14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS

Target Background

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.