Recombinant Human 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8), Truncated

Uniprot Id

Q16880

Target Species

Human

Target Name

UGT8

Target Full Name

2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Target Function

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides.

Target Subcellular Location

Membrane; Single-pass membrane protein. Endoplasmic reticulum.

Target Protein Families

UDP-glycosyltransferase family

Target Synonyms

UGT8; CGT; UGT4; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase

Target Background

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene.