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The recombinant Human PSMD14 was expressed with the amino acid range of 1-310. The calculated molecular weight for this PSMD14 protein is 79.2 kDa. Expression of this PSMD14 protein is conducted in baculovirus. The N-terminal MBP tag and C-terminal 6xHis tag was fused into the coding gene segment of PSMD14, making it easier to detect and purify the PSMD14 recombinant protein in the later stages of expression and purification.Research on PSMD14 (26S proteasome non-ATPase regulatory subunit 14) covers multiple areas. Many researchers focus on the precise regulatory mechanisms of PSMD14 in the 26S proteasome, including its position in degradation pathways and interactions with other subunits. Meanwhile, the role of PSMD14 in diseases is a significant area of interest, particularly in cancer and neurodegenerative disorders. These studies contribute to a deeper understanding of the biological functions of PSMD14, offering new directions for the treatment of related diseases.
The recombinant Human PSMD14 was expressed with the amino acid range of 1-310. The calculated molecular weight for this PSMD14 protein is 79.2 kDa. Expression of this PSMD14 protein is conducted in baculovirus. The N-terminal MBP tag and C-terminal 6xHis tag was fused into the coding gene segment of PSMD14, making it easier to detect and purify the PSMD14 recombinant protein in the later stages of expression and purification.Research on PSMD14 (26S proteasome non-ATPase regulatory subunit 14) covers multiple areas. Many researchers focus on the precise regulatory mechanisms of PSMD14 in the 26S proteasome, including its position in degradation pathways and interactions with other subunits. Meanwhile, the role of PSMD14 in diseases is a significant area of interest, particularly in cancer and neurodegenerative disorders. These studies contribute to a deeper understanding of the biological functions of PSMD14, offering new directions for the treatment of related diseases.
| Cat.No | ACP05168 | Target Name | PSMD14 |
|---|---|---|---|
| Target Synonyms | 14; Proteasome 26S subunit non ATPase 14; PSDE_HUMAN; Psmd14; RPN11; Testis tissue sperm binding protein Li 69n, 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1; 26S proteasome-associated PAD1 homolog; PAD1; PAD1, homolog of; POH1; Proteasome (prosome, macropain) 26S subunit, non-ATPase, yeast | Form | Liquid or Lyophilized powder |
| Expression System | Baculovirus | Expression Range | 1-310aa |
| Mol Weight | 79.2 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00487 |
|---|
Uniprot Id
O00487
Target Species
Human
Target Name
PSMD14
Target Full Name
26S proteasome non-ATPase regulatory subunit 14
Target Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Target Protein Families
Peptidase M67A family, PSMD14 subfamily
Target Tissue Specificity
Widely expressed. Highest levels in heart and skeletal muscle.
Target Research Area
Cell Biology
Target Synonyms
26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1; 26S proteasome-associated PAD1 homolog; PAD1; PAD1, yeast, homolog of; POH1; Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Proteasome 26S subunit non ATPase 14; PSDE_HUMAN; Psmd14; RPN11; Testis tissue sperm binding protein Li 69n
Target Background
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2.
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