Recombinant Human 3-mercaptopyruvate sulfurtransferase (MPST)

Cat.No	ACP23765	Target Name	MPST
Target Synonyms	3 mercaptopyruvate sulfurtransferase; 3-mercaptopyruvate sulfurtransferase; Human liver rhodanese; Mercaptopyruvate sulfurtransferase; MGC24539; MPST; MST; THTM_HUMAN; TST2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-297
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23765

Target Name

MPST

Target Synonyms

3 mercaptopyruvate sulfurtransferase; 3-mercaptopyruvate sulfurtransferase; Human liver rhodanese; Mercaptopyruvate sulfurtransferase; MGC24539; MPST; MST; THTM_HUMAN; TST2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-297

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P25325

Background Information

Uniprot Id

P25325
Target Species

Human
Target Name

MPST
Target Full Name

3-mercaptopyruvate sulfurtransferase
Target Function

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.
Target Involvement

Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4973015, PubMed:4690911 and PubMed:6945862). Some cases have associated mental retardation (PubMed:4973015 and PubMed:6945862).
Target Subcellular Location

Cytoplasm. Mitochondrion. Cell junction, synapse, synaptosome.
Target Synonyms

3 mercaptopyruvate sulfurtransferase; 3-mercaptopyruvate sulfurtransferase; Human liver rhodanese; Mercaptopyruvate sulfurtransferase; MGC24539; MPST; MST; THTM_HUMAN; TST2
Target Background

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.

Recombinant Human 3-mercaptopyruvate sulfurtransferase (MPST)

Specifications

Immunogen Information

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