Recombinant Human 39S ribosomal protein L20, mitochondrial (MRPL20), Truncated

Uniprot Id

Q9BYC9

Target Species

Human

Target Name

MRPL20

Target Full Name

Large ribosomal subunit protein bL20m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Bacterial ribosomal protein bL20 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

MRPL20; 39S ribosomal protein L20; mitochondrial; L20mt; MRP-L20; Mitochondrial large ribosomal subunit protein bL20m

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms.