Recombinant Human 39S ribosomal protein L21, mitochondrial (MRPL21)

Uniprot Id

Q7Z2W9

Target Species

Human

Target Name

MRPL21

Target Full Name

Large ribosomal subunit protein bL21m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Bacterial ribosomal protein bL21 family

Target Synonyms

MRPL21; 39S ribosomal protein L21; mitochondrial; L21mt; MRP-L21; Mitochondrial large ribosomal subunit protein bL21m

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD).